SpamAssassin uses header analysis, text analysis, blacklists, a spam-tracking database, and self-learning Bayesian spam analysis to quickly and accurately identify and tag spam.
The easiest way for a local user to use SpamAssassin is to place the following line near the top of the ~/.procmailrc file:
INCLUDERC=/etc/mail/spamassassin/spamassassin-default.rc
The /etc/mail/spamassassin/spamassassin-default.rc contains a simple Procmail rule that activates SpamAssassin for all incoming email. If an email is determined to be spam, it is tagged in the header as such and the title is prepended with the following pattern:
*****SPAM*****
Since SpamAssassin is a Perl script, it may be necessary on busy servers to use the binary SpamAssassin daemon (spamd) and client application (spamc). To start the spamd daemon, type the following command as root: /sbin/service spamassassin start and make sure the spamassassin is set to autostart at booting time
To configure Procmail to use the SpamAssassin client application instead of the Perl script, place the following line near the top of the ~/.procmailrc file. For a system-wide configuration, place it in /etc/procmailrc:
INCLUDERC=/etc/mail/spamassassin/spamassassin-spamc.rc
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source:http://linuxpoison.blogspot.com/2009/03/13578175717166.html